Liquid-Filled Two-Piece Capsules
Liquid-filled two-piece capsules present pharmaceutical and nutritional supplement scientists with a tool to effectively formulate poorly soluble drugs and supplements, while reducing development time and costs. Liquid filling also offers the ability to control R&D compounds, which are expensive and in limited supply.
Using Qualicaps® equipment and capsules, ACP can offer two options:
Gelatin Capsules: The market standard for many years
- High-quality product which matches the stringent requirements of the pharmaceutical industry
- Excellent performance on high-speed capsule filling and sealing machines
- Can be filled with SSM formulations up to 70° C
- Compatible with a range of excipients for improving bioavailability of poorly soluble drugs
Quali-V® Capsules: Hypromellose capsules made from plant-derived materials
- Proven pharmaceutical performance
- Meets all compendia dissolution requirements
- Compatible with a wider range of excipients than gelatin
- Preferred for hygroscopic fills
- Exceptional for low humidity applications, no brittleness
- Maintains shell mechanical strength at low moisture contents
- Can be filled with SSM formulations up to 80° C
- Ideal for new drug development
Benefits of Liquid-Filled Two-Piece Capsules
- Simple and cost effective formulation. Liquid capsules require no binders, lubricants, or plasticizers commonly found in traditional solid-dosage forms and soft gels. Aqueous and Non-aqueous liquids to semi-solids can be filled and banded.
- Absorption and bioavailability are enhanced. You’re API is already in solution or dispersed suspension.
- Integrated tamper proofing. Banded capsules provide a non-permeable barrier retarding tampering.
- Liquid-Filled Two-Piece Capsules are better than soft gel capsules. Thinner wall construction allows for smaller capsule sizes and more efficient and complete dissolution over soft gels.
- Unique branding opportunities. Nearly infinite choices of capsule and banding colors provide a wealth of product differentiation options. From clear capsules and clear bands to two color capsules and contrasting band color—the combinations are endless.
Contact us today. Once the project is defined, we’ll have a detailed quotation to you within 48 hours.
|
